Ring-stage growth arrest: Metabolic basis of artemisinin tolerance in Plasmodium falciparum
Summary: The emergence and spread of artemisinin-tolerant malaria parasites threatens malaria control programmes worldwide.Mutations in the propeller domain of the Kelch13 protein confer Plasmodium falciparum artemisinin resistance (ART-R).ART-R is linked to the reduced susceptibility of temporary growth-arrested ring-stage Demi Tasse Spoons parasi